Zidovudine 1 % (200 mg/20 ml) Inj
Trade Name
Prescriber Category
:
:
Retrovir
A
Department
Antimicrobial Restriction
:
:
ID, O&G
N/A
INDICATION (BLUE BOOK / UKK)
To reduce the rate of maternal-foetal transmission of HIV in
(I) HIV-positive pregnant women over 14 wks of gestation.
(2) their newborn infants.
DOSING FOR ADULTS GUIDE [DIAMS HSgB]
N/A
RENAL DOSE ADJUSTMENT IN ADULTS GUIDE [DIAMS HSgB]
N/A
IV TO PO GUIDE [DIAMS HSgB]
N/A
EXTENDED INFUSION GUIDE [DIAMS HSgB]
In-progress
SPECIAL MONITORING & PRECAUTION GUIDE [DIAMS HSgB]
In-progress
ALTERNATIVE DOSING (BLUE BOOK / HSgB DRUG LIST)
(1) Prophylaxis of maternal-foetal HIV transmission during labour and delivery Adult: Loading dose: 2 mg/kg, followed by continuous infusion of 1 mg/kg/hr until umbilical cord is clamped. If caesarean section is planned, start the IV infusion 4 hr before the operation. Renal and Hepatic impairment: Dose reduction may be needed. HIV infection (to be discuss: not in indication) Adult: 1-2 mg/kg every 4 hr, given as 2-4 mg/ml infusion over 1 hr. Child: As continuous infusion: 20 mg/m2/hr. Alternatively, as intermittent infusion: 120 mg/m2 every 6 hr. Renal impairment: Haemodialysis or peritoneal dialysis: 1 mg/kg every 6-8 hr. (2) Prophylaxis of HIV infection in neonates Child: Neonates: 1.5 mg/kg every 6 hr. Start treatment within 12 hr after birth and continue for 1st 6 wk of life. Dose to be given via IV infusion over 30 minutes. Renal impairment: Dose adjustment may be needed.