Voriconazole 200 mg Inj
Trade Name
Prescriber Category
:
:
Vfend
A*
Department
Antimicrobial Restriction
:
:
ID
Red Category (ID)
INDICATION (BLUE BOOK / UKK)
(i) Treatment of immunocompromised patients with progressive, possibly life-threatening infections such as invasive aspergillosis, fluconazole-resistant serious invasive candidiasis, Candidiasis of the esophagus, serious fungal infections caused by Scedasporium spp & Fusarium spp. (ii) Prevention of breakthrough fungal infections in febrile high-risk neutropenic patients.
DOSING FOR ADULTS GUIDE [DIAMS HSgB]
Loading Dose:
6 mg/kg IV q12h for 2 dose, then
Maintenance Dose:
4 mg/kg IV q12h
RENAL DOSE ADJUSTMENT IN ADULTS GUIDE [DIAMS HSgB]
CrCl <50 ml/min:
IV Voriconazole is not recommended by the manufacturer because of potential toxicity due to the accumulation of sulfobutylether cyclodextrin (vehicle of IV Voriconazole).
Switch patients with CrCl <50 ml/min to Oral Voriconazole when feasible. No need for dosage adjustment when the oral dose is used.
IV TO PO GUIDE [DIAMS HSgB]
Loading Dose with Oral Voriconazole has not been studied.
Direct dosage conversion of IV Voriconazole to Oral Voriconazole can be permitted. (Usual oral maintenence dose: 200-300 mg PO q12h)
Bioavailability: >90%
EXTENDED INFUSION GUIDE [DIAMS HSgB]
In-progress
SPECIAL MONITORING & PRECAUTION GUIDE [DIAMS HSgB]
In-progress
ALTERNATIVE DOSING (BLUE BOOK / HSgB DRUG LIST)
Adult and Children 12 years and greater: Loading dose: 6 mg/kg 12 hourly for first 24 hours. Maintenance: i) 4 mg/kg 12 hourly ii) 3 mg/kg 12 hourly. Dose may be increased to 4 mg/kg 12 hourly if response is inadequate. Children aged 2years to <12years with normal hepatic and renal function: No loading dose needed; 7mg/kg 12hourly