Vancomycin HCl 500 mg Inj

Trade Name

Prescriber Category

Vancocin

Department

Antimicrobial Restriction

Yellow Category

INDICATION (BLUE BOOK / UKK)

i) Treatment of infections due to susceptible gram-positive organisms whicih cannot be treated with other agens (eg. MRSA and Enterococcus sp.) ii) Treatment of severe staphylococcal infections in patients who cannot receive or who have failed to respond to penicillins and cephalosporin

DOSING FOR ADULTS GUIDE [DIAMS HSgB]

1. Systemic infection:
a) Loading Dose:
25 mg/kg IV STAT (range: 20-30 mg/kg)

b) Maintenence Dose:
15-20 mg/kg IV q8-12h (not to exceed 2 gm/dose)

2. Clostridium difficile associated Diarrhoea (CDI or CDAD):
125-500 mg PO q6h

RENAL DOSE ADJUSTMENT IN ADULTS GUIDE [DIAMS HSgB]

Systemic Infection:
CrCl 50-59 ml/min:
20-25 mg/kg IV LD, then 15 mg/kg IV q12h

CrCl 30-49 ml/min:
20-25 mg/kg IV LD, then 15 mg/kg q24h or 7.5 mg/kg IV q12h

CrCl 15-29 ml/min:
20 mg/kg IV LD, then 15mg/kg IV q48h or 7.5 mg/kg q24h

CrCl <15 ml/min or HD:
Same day HD: 15-20 mg/kg, top up 5 mg/kg post HD
Next day HD or HD in 2 days: 25 mg/kg

Clostridium difficile associated Diarrhoaea (CDI or CDAD):
No dosage adjustment required (minimal systemic absorption)

IV TO PO GUIDE [DIAMS HSgB]

N/A

EXTENDED INFUSION GUIDE [DIAMS HSgB]

In-progress

SPECIAL MONITORING & PRECAUTION GUIDE [DIAMS HSgB]

In-progress

ALTERNATIVE DOSING (BLUE BOOK / HSgB DRUG LIST)

Slow IV infusion, ADULT: 15-20mg/kg q 8-12 hours, not to exceed 2gm per dose.
Neonate up to 1 wk: 15 mg/kg initially then 10 mg/kg every 12 hrs. Infant 1-4 wks: 15 mg/kg initially then 10 mg/kg every 8 hrs. Child over 1 month: 10 mg/kg every 6 hrs.

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