Rifampicin 300 mg Cap
Trade Name
Prescriber Category
:
:
Rifadin
B
Department
Antimicrobial Restriction
:
:
N/A
INDICATION (BLUE BOOK / UKK)
Only for: (1) Tuberculosis patients (2) Leprosy (3) Prophylaxis for meningococcal meningitis.
DOSING FOR ADULTS GUIDE [DIAMS HSgB]
Mycobacterium or MRSA Infection:
10 mg/kg IV or PO q24h
(usually 600 mg IV or PO q24h)
*Round up to the nearest 150 mg
*For mRSA bacteremia, add Rifampicin after culture clearance
Prosthetic Joint Infection or Prosthetic Valve Endocarditis:
300 - 450 mg IV or PO q1h
With HIV PIs:
Not recommended - consider changing to Rifabutin
RENAL DOSE ADJUSTMENT IN ADULTS GUIDE [DIAMS HSgB]
<10 ml/min or HD:
Usual dose
Some recommend a 50% decrease in dose
IV TO PO GUIDE [DIAMS HSgB]
N/A
EXTENDED INFUSION GUIDE [DIAMS HSgB]
In-progress
SPECIAL MONITORING & PRECAUTION GUIDE [DIAMS HSgB]
In-progress
ALTERNATIVE DOSING (BLUE BOOK / HSgB DRUG LIST)
i) Tuberculosis ADULT: Daily doses: 10mg/kg/day Body weight doses: 10-15/kg/day CHILD: 10 - 20 mg/kg body weight daily in 1 - 2 doses. Maximum daily dose : 600mg Directly observed therapy (DOT): 10 mg/kg twice weekly or 3 times/week. Maximum: 600 mg ii) Leprosy: ADULT: 600 mg/day CHILDREN: 10mg/kg iii) Prophylaxis for meningococcal meningitis: ADULT: 600 mg twice daily for 2 days CHILDREN: 10mg/kg twice daily for 2 days INFANT: 5mg/kg twice daily for 2 day