Itraconazole 10 mg/ml Oral Solution
Trade Name
Prescriber Category
:
:
Sporanox
A*
Department
Antimicrobial Restriction
:
:
FARMASI
(Must be discuss with ID specialist/ consultant before start)
Red Category (ID)
INDICATION (BLUE BOOK / UKK)
Treatment of: (1) Oral or oesophageal candidiasis. (2) Fluconazole resistant and/or oesophageal candidiasis.
DOSING FOR ADULTS GUIDE [DIAMS HSgB]
Usual dose:
100-200 mg PO q12h
Consolidation therapy for cryptococcal meningitis, histoplasmosis or penicilliosis:
200 mg PO q8h for 3 days,
followed by 200 mg PO q12h
Maintenance therapy / secondary prophylaxis for cryptococcal meningitis / histoplasmosis / penicilliosis:
200 mg PO q24h
Treatment of Oropharyngeal candidiasis (oral thrush) / Oesophageal candidiasis:
200 mg PO q24h
Pulse regimen for Onychomycoses:
200 mg PO q12h x 1 week per month
RENAL DOSE ADJUSTMENT IN ADULTS GUIDE [DIAMS HSgB]
CrCl <10 ml/min:
50% of normal dose PO q12h
HD:
100 mg PO q12-24h
[No significant itraconazole removal during HD]
IV TO PO GUIDE [DIAMS HSgB]
N/A
EXTENDED INFUSION GUIDE [DIAMS HSgB]
In-progress
SPECIAL MONITORING & PRECAUTION GUIDE [DIAMS HSgB]
In-progress
ALTERNATIVE DOSING (BLUE BOOK / HSgB DRUG LIST)
i) 200 mg daily for 1 week. If no response after 1 week, continue treatment for another week ii) 100 - 200 mg twice daily for 2 weeks. If no response after 2 weeks, continue treatment for another 2 weeks. The 400 mg daily dose should not be used for more than 14 days if there are no signs of improvement