Imipenem 500 mg + Cilastatin 500 mg Inj
Trade Name
Prescriber Category
:
:
Tienam
A*
Department
Antimicrobial Restriction
:
:
-
Yellow Category
INDICATION (BLUE BOOK / UKK)
Severe infections caused by susceptible pathogens especially useful in infections involving ESBL organisms. NOT TO BE USED FOR PROPHYLAXIS.
DOSING FOR ADULTS GUIDE [DIAMS HSgB]
Usual dose:
500 mg IV q6h
High dose for severe infections or for bacterial species with intermediate susceptibility:
1,000 mg IV q6-8h
Consider extended infusion.
Refer to DIAMS - Extended infusion [in progress].
RENAL DOSE ADJUSTMENT IN ADULTS GUIDE [DIAMS HSgB]
1. Original dose: 500 mg q6h
CrCl 30-59 ml/min:
500 mg IV q8h
CrCl 15-29 ml/min:
250 mg IV q6h or 500 mg IV q12h
CrCl <15 ml/min:
Not recommended, unless HD is instituted within 48h
HD:
250 mg IV q6h or 500 mg IV q12h
[Administer dose after HD on dialysis days]
2. Original dose: 1,000 mg IV q8h
CrCl 60-90 ml/min:
500 mg IV q6h
CrCl 30-59 ml/min:
500 mg IV q8h
CrCl 15-29 ml/min:
500 mg IV q12h
CrCl <15 ml/min:
Not recommended, unless HD is instituted within 48h
HD:
250 mg IV q6h or 500 mg IV q12h
[Administer dose after HD on dialysis days]
3. Original dose: 1,000 mg q6h
CrCl 60-90 ml/min:
750 mg IV q6h
CrCl 30-59 ml/min:
500 mg IV q6h
CrCl 15-29 ml/min:
500 mg IV q12h
CrCl <15 ml/min:
Not recommended, unless HD is instituted within 48h
HD:
500 mg IV q12h
[Administer dose after HD on dialysis days]
IV TO PO GUIDE [DIAMS HSgB]
N/A
EXTENDED INFUSION GUIDE [DIAMS HSgB]
In-progress
SPECIAL MONITORING & PRECAUTION GUIDE [DIAMS HSgB]
In-progress
ALTERNATIVE DOSING (BLUE BOOK / HSgB DRUG LIST)
Based on type or severity of infection, susceptibility of pathogen(s) and patient condition including body weight and renal function. ADULT: 1 - 2 g/day in 3 - 4 divided doses. Maximum: 4 g/day or 50 mg/kg/day. Infusion rate: less than 500 mg dose: over 20 - 30 minutes, more than 500 mg: dose over 40 - 60 minutes. CHILDREN: ≥ 40kg body weight should receive adult doses. CHILDREN AND INFANTS: <40kg body weight should receive 15mg/kg at six hour intervals. The total daily dose should not exceed 2g.