Gentamicin Sulph 80 mg/2 ml lnj

Trade Name

Prescriber Category

Department

Antimicrobial Restriction

Yellow Category

INDICATION (BLUE BOOK / UKK)

Infections caused by susceptible organism.

DOSING FOR ADULTS GUIDE [DIAMS HSgB]

Single Daily Dosing (SDD):
5-7 mg/kg IV q24h
OR
7 mg/kg IV q24h (if criticall ill)

Multiple Daily Dosing (MDD):
LD: 2 mg/kg
MD: 1.5-2 mg/kg IV q8h

Synergistic Dosing:
1 mg/kg IV q8h
OR
3 mg/kg IV q24h (for native valve infective endocarditis)

RENAL DOSE ADJUSTMENT IN ADULTS GUIDE [DIAMS HSgB]

1. SDD:
CrCl 60-80 ml/min:
4 mg/kg IV q24h

CrCl 40-60 ml/min:
3.5 mg/kg IV q24h

CrCl 30-40 ml/min:
2.5 mg/kg IV q24h

CrCl <30 ml/min:
Refer to Gentamicin MDD

2. MDD:
CrCl 40-60 ml/min:
1.5 – 2 mg/kg IV q12h

CrCl 20-40 ml/min:
1.5 – 2 mg/kg IV q24h

CrCl <20 ml/min:
1.5 – 2 mg/kg IV q48 – 72h

HD:
Loading dose 2-3 mg/kg, followed by 1-2 mg/kg IV q48-72h
Redose when level < 2 mg/L. (< 4.2 μmol/L)] for UTI, 3-5 mg/L (< 6.3-10.5 μmol/L) for gram negative infection.
[Administer dose after HD on day of dialysis]

3. Synergistic Dosing:
CrCl 40-60 ml/min:
1 mg/kg IV q12h

CrCl 20-40 ml/min:
1 mg/kg IV q24h

CrCl <20 ml/min:
1 mg/kg IV load
Redose when level < 1 mg/L. (< 2.1 μmol/L)

HD:
1 mg/kg IV q48-72h
Redose when level < 1 mg/L. (< 2.1 μmol/L)
[Administer dose after HD on day of dialysis]

IV TO PO GUIDE [DIAMS HSgB]

N/A

EXTENDED INFUSION GUIDE [DIAMS HSgB]

In-progress

SPECIAL MONITORING & PRECAUTION GUIDE [DIAMS HSgB]

In-progress

ALTERNATIVE DOSING (BLUE BOOK / HSgB DRUG LIST)

ADULT: 3 - 5 mg/kg/day 8 hourly IM or IV. CHILD up to 2 weeks: 3mg/kg every 12 hours; 2 weeks - 12 years: 2 mg/kg 8 hourly

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