Fosfomycin 3g Sachet (Granules)
Trade Name
Prescriber Category
:
:
Monurol
A*
Department
Antimicrobial Restriction
:
:
ID (halt purchase)
Red Category (ID)
INDICATION (BLUE BOOK / UKK)
Treatment of acute uncomplicated lower urinary tract infections (acute cystitis) in females of 18 years of age and older caused by multidrug resistant (MDR) Escherichia coli or Enterococcus faecalis who are candidates for carbapenems or colistin.
DOSING FOR ADULTS GUIDE [DIAMS HSgB]
Uncomplicated UTI:
3 gm sachet PO x 1 dose
Complicated UTI:
3 gm sachet PO every 2-3 days x 3 doses
RENAL DOSE ADJUSTMENT IN ADULTS GUIDE [DIAMS HSgB]
1. Uncomplicated UTI:
No dosage adjustment
2. Complicated UTI:
CrCl 10-50 ml/min:
Limited data.
Consider 3 gm sachet OI every 3 days.
CrCl <10 ml/min:
No data, given prolonged half-life consider dose adjustment or avoid due to decreased urinary excretion.
HD:
Redose after dialysis, due to removal during HD.
IV TO PO GUIDE [DIAMS HSgB]
N/A
EXTENDED INFUSION GUIDE [DIAMS HSgB]
In-progress
SPECIAL MONITORING & PRECAUTION GUIDE [DIAMS HSgB]
In-progress
ALTERNATIVE DOSING (BLUE BOOK / HSgB DRUG LIST)
Acute uncomplicated lower UTI: - 1 sachet as single dose. Recurrent or other clinically problematic cystitis - Up to 2 doses every 24 hr. On empty stomach at bedtime.