Cycloserine 250 mg Cap
Trade Name
Prescriber Category
:
:
A*(Respiratory physician)
Department
Antimicrobial Restriction
:
:
ID
N/A
INDICATION (BLUE BOOK / UKK)
Multi-Drug Resistance Tuberculosis treatment failure. (For respiratory physicians)
DOSING FOR ADULTS GUIDE [DIAMS HSgB]
10-15 mg/kg/day PO in two divided dose
(Maximum 1,000 mg/day; start at 250mg once daily and increase dose per tolerability)
RENAL DOSE ADJUSTMENT IN ADULTS GUIDE [DIAMS HSgB]
CrCl ≥50
Usual dose
CrCl 30-49 ml/min:
250-500 mg PO q12-24h [Dosing interval poorly defined]
CrCl 11-29 ml/min:
250 mg PO q24h
CrCl <10 ml/min:
Not recommended (unless patient is receiving HD)
HD:
250 mg PO q24h
or
500 mg PO three times per week
IV TO PO GUIDE [DIAMS HSgB]
N/A
EXTENDED INFUSION GUIDE [DIAMS HSgB]
In-progress
SPECIAL MONITORING & PRECAUTION GUIDE [DIAMS HSgB]
In-progress
ALTERNATIVE DOSING (BLUE BOOK / HSgB DRUG LIST)
ADULT: Initial: 250 mg every 12 hours for 14 days, then administer 0.5 - 1 g daily in 2 divided doses for 18 - 24 months (maximum daily dose: 1 g). CHILD: 2-12 yr: 5 mg/kg bid; 12-18 yr: 250 mg bid for 2 wk then adjusted to a max dose of 1 g daily