Cefoperazone 500 mg & Sulbactam 500 mg Inj
(A.K.A. Sulperazone)
Trade Name
Prescriber Category
:
:
Sulperazon
A
Department
Antimicrobial Restriction
:
:
-
Yellow Category
INDICATION (BLUE BOOK / UKK)
i) Treatment of infections due to multi-drug resistance pathogens producing B-lactamase
ii) Treatment of infections caused by Acinetobacter species
DOSING FOR ADULTS GUIDE [DIAMS HSgB]
Severe GNR Infections:
3-4 gm IV q6h
MRO Acinetobacter Treatment:
4 gm IV q6h
(Sulbactam 8 gm/day)
RENAL DOSE ADJUSTMENT IN ADULTS GUIDE [DIAMS HSgB]
1. Severe GNR Infections (Original Dose 3-4 gm IV q6h);
CrCl 30-50 ml/min:
2-3 gm IV q6h
CrCl < 30 ml/min or HD:
1-2 gm IV q6h
2. MRO Acinetobacter Treatment (Original Dose 4 gm IV q6h (Sulbactam 8 gm/day)):
CrCl 30-50 ml/min:
3 gm IV q6h
(Sulbactam 6 gm/day)
CrCl < 30 ml/min or HD:
2 gm IV q6h
(Sulbactam 4 gm/day)
IV TO PO GUIDE [DIAMS HSgB]
N/A
EXTENDED INFUSION GUIDE [DIAMS HSgB]
In-progress
SPECIAL MONITORING & PRECAUTION GUIDE [DIAMS HSgB]
In-progress
ALTERNATIVE DOSING (BLUE BOOK / HSgB DRUG LIST)
ADULT:
1 - 2 g twice daily.
In severe or refractory infections the daily dosage of sulbactam/cefoperazone may be increased up to 8 g (4 g cefoperazone activity)
CHILD:
40 - 80 mg/kg/day in 2 to 4 equally divided doses; in serious or refractory infections, may increase to 160mg/kg/d in 2 - 4 equally divided doses.