Cefepime 1 g Inj
Trade Name
Prescriber Category
:
:
Maxipime
A*
Department
Antimicrobial Restriction
:
:
Yellow Category
INDICATION (BLUE BOOK / UKK)
Febrile neutropenia, septicaemia, lower respiratory tract infection, urinary tract infection, skin and skin structure infections, gynaecologic and intra-abdominal infections
DOSING FOR ADULTS GUIDE [DIAMS HSgB]
Mild to moderate infections, UTI:
1 gm IV q8-12h
Intra-abdominal infection, Diabetic foot infection, SSTI, Osteomyelitis, Prosthetic joint infection:
2 gm IV q8-12h
Bacteremia, Pneumonia, Sepsis, Severe infections, Suspected/ confirmed Pseudomonas infection, CNS infections, Febrile neutropenia, Cystic fibrosis or Obese patients:
2 gm IV q8h
RENAL DOSE ADJUSTMENT IN ADULTS GUIDE [DIAMS HSgB]
1. Original dose 1 gm IV q8-12h:
CrCl 30-60 ml/min:
1 gm IV q12h
CrCl 10-29 ml/min:
1 gm IV q24h
CrCl < 10 ml/min:
500 mg IV q24h
HD
1gm once, then 500 mg IV q24h
[Administer dose after HD on dialysis day]
2. Original Dose 2 gm IV q12h:
CrCl 30-60 ml/min:
1 gm IV q12h or 2 gm IV q24h
CrCl 10-29 ml/min:
1 gm IV q24h
CrCl < 10 ml/min:
500 mg IV q24h
HD
1 gm once, then 500 mg IV q24h
[Administer dose after HD on dialysis day]
3. Original dose: 2 gm IV q8h
CrCl 30-60 ml/min:
1 gm IV q8h or 2 gm IV q12h
CrCl 10-29 ml/min:
1 gm IV q12h or 2 gm IV q24h
CrCl < 10 ml/min or HD:
1 gm q24h
[Administer dose after HD on dialysis day]
IV TO PO GUIDE [DIAMS HSgB]
IV Cefepime 2 g q8-12h:
--> Amoxicillin/Clavulanate 625 mg TDS
or
--> Sultamicillin 750 mg BD
or
For definitive Pseudomonas infection:
--> Ciprofloxacin* 500-750 mg BD
Bioavailability:
Amoxicillin: 80%
Clavulanate: 30-98%
Sultamicillin: 80%
Ciprofloxacin: 50-85%
EXTENDED INFUSION GUIDE [DIAMS HSgB]
In-progress
SPECIAL MONITORING & PRECAUTION GUIDE [DIAMS HSgB]
In-progress
ALTERNATIVE DOSING (BLUE BOOK / HSgB DRUG LIST)
ADULT:
1 - 2 g twice daily for most infections.
For severe infections including febrile neutropenia: 2 g 3 times daily.
CHILD:
2 mth - 16 yr: ≤40 kg: 50 mg/kg every 8-12 hr for 7-10 days