Benzylpenicillin
1 mega unit (600 mg) & 5 mega units (3 g) Inj
(A.K.A. Penicillin G or C-Pen)
Trade Name
Prescriber Category
:
:
B
Department
Antimicrobial Restriction
:
:
Green Category
INDICATION (BLUE BOOK / UKK)
(1) Infections caused by susceptible organisms.
(2) Infective endocarditis.
DOSING FOR ADULTS GUIDE [DIAMS HSgB]
Leptospirosis
1.5-2 million units IV q6h
SSTI:
2–4 million units IV q4-6h
Infective endocarditis (Penicillin susceptible Streptococci):
3 million units IV q4h
Infective endocarditis (Streptococci relatively resistant to Penicillin, NVS), Neurosyphilis, Ocular syphilis or CNS Infection:
4 million units IV q4h
RENAL DOSE ADJUSTMENT IN ADULTS GUIDE [DIAMS HSgB]
1. Mild to moderate infection
CrCl <10 ml/min:
Administer a full dose, followed by 50% of the normal dose q6h
HD:
1 million units IV q6h
2. Serious infection
CrCl 10–50 ml/min:
2–3 million units IV q4h
CrCl <10 ml/min or HD:
2 million units IV q4–6h
IV TO PO GUIDE [DIAMS HSgB]
IV Benzylpenicillin
1-2 mega units q6h --> Tab Phenoxymethylpenicillin
250 mg QID/500 mg BD
3-4 mega units q4-6h --> Tab Phenoxymethylpenicillin 500 mg BD
or
IV Benzylpenicillin --> Cap Amoxicillin 500 mg TDS
Bioavailability;
Phenoxymethylpenicillin: 60-73%
Amoxicillin: 80%
EXTENDED INFUSION GUIDE [DIAMS HSgB]
In-progress
SPECIAL MONITORING & PRECAUTION GUIDE [DIAMS HSgB]
In-progress
ALTERNATIVE DOSING (BLUE BOOK / HSgB DRUG LIST)
i) ADULT:
600 mg - 3600 mg (1 - 6 mega units) daily, divided into 4 to 6 doses. Higher doses (24 mega units) in divided doses may be given in serious infections such as meningitis.
CHILD:
1 month to 12 years old: 100 mg/kg/day in 4 divided doses, not exceeding 4 g/day;
Infants 1 -4 weeks: 75 mg/kg/day in 3 divided doses;
Newborn Infants: 50 mg/kg/day in 2 divided doses
ii) 7.2 to 12 g (12 - 20 mega units) may be given daily in divided doses