Ampicilin & Sulbactam 1.5 g Inj
Trade Name
Prescriber Category
:
:
Unasyn
A
Department
Antimicrobial Restriction
:
:
-
Green Category
INDICATION (BLUE BOOK / UKK)
Treatment of susceptible bacterial infections
DOSING FOR ADULTS GUIDE [DIAMS HSgB]
Usual dose:
3 gm IV q6-8h
*3 gm IV q6h is preferred for serious infections or treatment of gram-negative infections
MRO Acinetobacter treatment:
3 gm IV q3-4h
or
9 gm IV q8h
RENAL DOSE ADJUSTMENT IN ADULTS GUIDE [DIAMS HSgB]
1. Original dose 3 gm IV q6-8h:
CrCl 15-29 ml/min:
3 gm IV q12h
CrCl < 15 ml/min or HD:
3 gm IV q24h
[Administer dose after HD on dialysis day]
2. Original dose 3 gm IV q4h:
CrCl 30-50 ml/min:
3 gm IV q6h
CrCl 15-29 ml/min:
3 gm IV q8h
CrCl < 15 ml/min or HD:
3 gm IV q12h
[Administer dose after HD on dialysis day]
3. Original dose: 3 gm IV q3h
CrCl 20-50 ml/min:
3 gm IV q4h
CrCl < 20 ml/min or HD
3 gm IV q6h
[Administer dose after HD on dialysis day]
4. Original dose 9 gm IV q8h:
CrCl 20-50 ml/min:
6 gm IV q8h
CrCl < 20 ml/min or HD:
6 gm IV q12h
[Administer dose after HD on dialysis day]
IV TO PO GUIDE [DIAMS HSgB]
IV Ampicillin/ Sulbactam
1.5 g q8h --> Cap. Ampicillin/ Sulbactam 375 mg BD
3 g q8h --> Cap. Ampicillin/ Sulbactam 375-750 mg BD
3 g q6h --> Cap. Ampicillin/ Sulbactam 750 mg BD
Bioavailability:
80%
EXTENDED INFUSION GUIDE [DIAMS HSgB]
In-progress
SPECIAL MONITORING & PRECAUTION GUIDE [DIAMS HSgB]
In-progress
ALTERNATIVE DOSING (BLUE BOOK / HSgB DRUG LIST)
ADULT:
1.5 - 12 g/day in divided doses 6 - 8 hourly.
Maximum: 4 g Sulbactam.
CHILD:
150-300 mg/kg/day 6 - 8 hourly.
NEONATES:
First week of life, 75 mg/kg/day in divided doses every 12 hour
Prophylaxis of surgical infections: 1.5 - 3 g at induction of anaesthesia. May be repeated 6 - 8 hourly.