Amphotericin B 50 mg Deoxycholate Inj
(A.K.A Conventional Ampho B)
Trade Name
Prescriber Category
:
:
Fungizone
A
Department
Antimicrobial Restriction
:
:
-
Yellow Category
INDICATION (BLUE BOOK / UKK)
Systemic fungal infections.
DOSING FOR ADULTS GUIDE [DIAMS HSgB]
Caution!
*There are 2 types of Ampho B in HSgB; Ampho B deoxycholate (conventional) & Ampho B lipid complex (ABLC). Please ensure that reference is made to the correct Ampho B.
*Liposomal Ampho B is not available in HSgB
Amphotericin B deoxycholate usual dose:
0.6–1.0 mg/kg IV q24h
Dosing for Opportunistic Infections:
Penicilliosis:
0.6-0.7 mg/kg IV q24h
Histoplasmosis
0.7-1.0 mg/kg IV q24h
Cryptococcal Meningitis:
0.7-1.0 mg/kg IV q24h
RENAL DOSE ADJUSTMENT IN ADULTS GUIDE [DIAMS HSgB]
No dosage adjustment necessary; consider alternative antifungals if renal insufficiency occurs during therapy despite adequate hydration.
IV TO PO GUIDE [DIAMS HSgB]
N/A
EXTENDED INFUSION GUIDE [DIAMS HSgB]
In-progress
SPECIAL MONITORING & PRECAUTION GUIDE [DIAMS HSgB]
In-progress
ALTERNATIVE DOSING (BLUE BOOK / HSgB DRUG LIST)
ADULT:
0.25 mg/kg/day by IV infusion,gradually increase if tolerated to 1mg/kg/day.
Maximum in severe cases: 1.5 mg/kg daily or on alternate days.
For neonates, lower doses are recommended