Amikacin 250 mg/2 ml Inj
Trade Name
Prescriber Category
:
:
Amikin
A
Department
Antimicrobial Restriction
:
:
-
Yellow Category
INDICATION (BLUE BOOK / UKK)
Infections caused by susceptible organism.
DOSING FOR ADULTS GUIDE [DIAMS HSgB]
Single Daily Dosing (SDD)
15 mg/kg IV q24h
or
Multiple Daily Dosing (MDD)
7.5mg/kg IV q12h
Use with caution in patients with renal insufficiency and family history of ototoxicity
RENAL DOSE ADJUSTMENT IN ADULTS GUIDE [DIAMS HSgB]
Adjust dose based on serum concentrations.
Target levels:
SDD:
Trough: <1 mg/L (< 1.7 μmol/L), Peak: ~60 mg/L (~102 μmol/L)
MDD: Trough: <10 mg/L (< 17 μmol/L) Peak: 20-30 mg/L (34-51 μmol/L)
1) SDD:
CrCl 60-80 ml/min:
12 mg/kg IV q24h
CrCl 40-60 ml/min:
7.5 mg/kg IV q24h
CrCl 30-40 ml/min:
4 mg/kg IV q24h
CrCl < 30 ml/min:
Refer to Amikacin MDD
2) MDD:
CrCl 10-50 ml/min:
7.5 mg/kg IV q24h
CrCl < 10 ml/min:
7.5 mg/kg IV q48h
HD:
7.5 mg/kg IV q48h
[Administer dose after HD on dialysis day.
Redose when level is <10 mg/L (< 17 μmol/L)]
IV TO PO GUIDE [DIAMS HSgB]
N/A
EXTENDED INFUSION GUIDE [DIAMS HSgB]
In-progress
SPECIAL MONITORING & PRECAUTION GUIDE [DIAMS HSgB]
In-progress
ALTERNATIVE DOSING (BLUE BOOK / HSgB DRUG LIST)
ADULT:
(IM or IV): 15 mg/kg/day 8 - 12 hourly for 7 - 10 days.
Maximum: 1.5 g/day.
CHILD:
15 mg/kg/day 8 - 12 hourly.
Maximum: 1.5 g/day.
NEONATES:
Initial loading dose of 10 mg/kg followed by 7.5 mg/kg/day 12 hourly. Maximum 15 mg/kg/day