Acyclovir 250 mg Inj
Trade Name
Prescriber Category
:
:
Zovirax
A*
Department
Antimicrobial Restriction
:
:
-
N/A
INDICATION (BLUE BOOK / UKK)
i) Treatment of Herpes Simplex & Varicella zoster infections
ii) Prophylaxis of Herpes Simplex infections in immune-compromised patients
DOSING FOR ADULTS GUIDE [DIAMS HSgB]
Serious Herpes Symplex (HSV) Infections:
5 mg/kg IV q8h
HSV Encephalitis & Varicella Zoster (VZV) Infections:
10 mg/kg IV q8h
RENAL DOSE ADJUSTMENT IN ADULTS GUIDE [DIAMS HSgB]
CrCl 26–50 ml/min:
100% of dose IV q12h
CrCl 10–25 ml/min:
100% of dose IV q24h
CrCl <10 ml/min:
50% of dose IV q24h
HD:
50% of dose IV q24h [Administer dose after HD on dialysis day]
IV TO PO GUIDE [DIAMS HSgB]
N/A
EXTENDED INFUSION GUIDE [DIAMS HSgB]
In-progress
SPECIAL MONITORING & PRECAUTION GUIDE [DIAMS HSgB]
In-progress
ALTERNATIVE DOSING (BLUE BOOK / HSgB DRUG LIST)
ADULT:
5 mg/kg by IV infusion 8 hourly for 5 days, doubled to 10mg/kg every 8 hourly in varicella-zoster in the immunocompromised and in simplex encephalitis (usually given for at least 10 days in encephalitis; possibly for 14 - 21 days).
NEONATE & INFANT up to 3 months with disseminated herpes simplex: 20mg/kg every 8 hourly for 14 days (21 days in CNS involvement), varicella-zoster 10-20mg/kg every 8 hourly usually for 7 days.
CHILD, 3 months - 12 years: Herpes simplex or Varicella Zoster: 250 mg/m2 8 hourly for 5 days, doubled to 500 mg/m2 8 hourly for varicella-zoster in the immunocompromised and in simplex encephalitis (usually given for 10 days in encephalitis)