Acyclovir
(200 mg or 800 mg Tab)
Trade Name
Prescriber Category
:
:
Zovirax
A/KK
Department
Antimicrobial Restriction
:
:
-
N/A
INDICATION (BLUE BOOK / UKK)
i) Treatment of Herpes Simplex & Varicella zoster infections
ii) Prophylaxis of Herpes Simplex infections in immune-compromised patients
DOSING FOR ADULTS GUIDE [DIAMS HSgB]
Herpes Zoster (HZV) & Varicella Zoster (VZV) Treatment:
800 mg PO five times/day
Herpes Symplex (HSV) Orolabial/Genital Lesions Treatment:
400 mg PO q8h
RENAL DOSE ADJUSTMENT IN ADULTS GUIDE [DIAMS HSgB]
1. Original dose: 800 mg PO five times/day
CrCl 10–25 ml/min:
800 mg PO q8h
CrCl <10 ml/min:
800 mg PO q12h
HD
800 mg PO q12h
[Administer dose after HD on dialysis day]
2. Original dose: 400 mg PO q8h
CrCl 10-25 ml/min:
200-400 mg PO q8h
CrCl <10 ml/min or HD:
200 mg PO q12h
IV TO PO GUIDE [DIAMS HSgB]
N/A
EXTENDED INFUSION GUIDE [DIAMS HSgB]
In-progress
SPECIAL MONITORING & PRECAUTION GUIDE [DIAMS HSgB]
In-progress
ALTERNATIVE DOSING (BLUE BOOK / HSgB DRUG LIST)
Indication
(i) Treatment for Herpes Simplex:
ADULT - 200mg 5 times daily;
In severely immune-compromised patients: dose can be doubled to 400 mg.
CHILD - two years and above should be given adult dosages, infants and children below two years old should be given half the adult dose.
(i) Treatment for Varicella Zoster:
ADULT - 800mg 5 times daily;
CHILD - 6 years and over: 800 mg four times daily,
CHILD 2 - < 6 years: 400 mg four times daily,
CHILD Under 2 years: 200 mg four times daily. Indication
(ii) Prophylaxis of Herpes Simplex infections in immune-compromised patients:
ADULT - immune-compromised patients: 200 mg four times daily. Severely immune-compromised patients: dose can be doubled to 400 mg.
CHILD - two years and above should be given adult dosages, infants and children below two years old should be given half the adult dose. Dosing is according to Product Information Leaflet.